Dominating the corner of Sixth and Main Streets is the three-story National Hotel Building. This building marks the western edge of the downtown commercial area. The hotel has a prominent location on Murray's most important street, one that connects the downtown with the Murray State University campus.

The National Hotel was constructed in 1929 in a simple version of the Classical Revival style. The main entrance to the hotel is located on the Sixth Street facade. This entrance has a central doorway topped with a fanlight and balanced with two multi-paned windows. All of this is surrounded by limestone blocks and topped by the original steel awning. On both sides of the central entranceway are doorways and commercial display windows. These provide access and visibility to the commercial establishments located on the first floor of the hotel. Each of these doorways has a limestone surround and a keystone. Most of the first floor windows have their original sashes, but these have been covered with modern siding. These regularly placed first floor windows and doors continue on the Main Street facade of the hotel.

A stone beltcourse runs along the building delineating the top of the first floor. The upper two floors of the hotel have regularly placed windows for
the hotel rooms. Smaller windows provide light for the bathrooms.
The original window sashes have been covered with plywood for protection. A second story stone beltcourse provides a sill for the second floor

windows. A stone cornice runs across the top of the building. Three- story brick pilasters mark each of the major corners of the building.

The first floor interior is mainly divided into commercial spaces and the hotel lobby. The lobby retains its original check-in desk and management offices. The upper floor hotel rooms retain their original lay-outs and details. A partial basement provides meeting room space and storage.